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Mg osteo 


Bone Solutions, Inc. (BSI) magnesium-based orthopedic technologies, Mg OSTEOCRETE, Mg OSTEOREVIVE and Mg OSTEOINJECT (Mg OSTEO Technologies) are injectable, moldable, and biocompatible bone void fillers. When mixed and molded/injected according to the instructions for use, they will harden in-situ at the defect site. Due to the presence of magnesium, the BSI bone void fillers have a unique resorption profile that provides stability, increases cell proliferation and advances mineralization, resulting in enhanced bone regeneration as demonstrated in a broad range of studies summarized here.

Why Magnesium

The addition of magnesium phosphate to calcium phosphate bone void fillers for orthopedic fracture fixation or augmentation procedures has demonstrated improved cellular reactivity in numerous studies. In vitro studies have highlighted the importance of the inclusion of both a magnesium phosphate and a calcium phosphate component for a resorbable cement intended for use as a bone void filler. The rationale behind this strategy is related to the release of magnesium ions from the magnesium phosphate component. It has been demonstrated that magnesium (1) increases the proliferation of bMSCs (bone marrow stromal cells), (2) improves the attachment and growth of osteoblasts, (3) stimulates the proteins involved in bone regeneration, (4) enhances new bone formation, and (5) advances bone mineralization. 

Mg OSTEO Technology

Mg OSTEO Material’s uniqueness is built around the inclusion of magnesium. Magnesium is slowly eluted from the material over time, which allows for active resorption (cell-mediated) in addition to passive resorption (dissolution). At a cellular level, magnesium directly impacts bone regeneration via established signaling pathways. The effect is increased mesenchymal stem cell proliferation, promotion of osteogenic differentiation, inducement of osteoblast activity, and advancement of mineralization. The end result is maximized breakdown of the Mg OSTEO Material and replacement with bone formation.

The crystallization reaction of Mg OSTEO Material yields a structural magnesium phosphate with superior osseous incorporation compared to standard calcium phosphate cements. When a bone void filler utilizes magnesium phosphate instead of calcium phosphate, the impact is monumental. Cellular attachment and proliferation are enhanced, the rate and effectiveness of osteogenesis is elevated, a higher resorption rate occurs and there is a greater degree of graft replacement with mineralized bone formation. The final outcome with a magnesium phosphate is improved bone regeneration.  


Injectable & Moldable

Optimized consistency for use in multiple orthopedic applications


Temperature Setting Control

Allows for optimal workability and curing time



Product easily identifiable

in situ


Excellent Binding Characteristics

Optimal product stability and fixation at operative site


Fully Synthetic Material

Enhanced quality control and product availablity with reduced patient morbidity


Thixotropic Properties

Easily manageable curing time allowing for intraoperative flexibility and reduction of waste



High Compressive Strength

Surface topography to support bone formation, enhancing structural stability and biocompatibility


Enhanced Bone Regeneration

Greater than 80% bone remodeling in 26 weeks*

* All claims based on critically sized rabbit lateral condyle defect model. It is unknown how results from the rabbit model compare with clinical results in humans.

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