At Mg Bone Solutions, we're proud to be different from the rest. We realize that there are numerous bone substitutes on the market, but we are definitely not like the others and here's why. Magnesium.
It's the integrated solution that is the basis of our entire portfolio and it truly sets us apart from the competition.
The Mg Difference
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Magnesium acts as a catalyst for the enzymes needed to build the bone matrix, the organic framework that supports bone mineralization. [1]
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Magnesium stimulates growth and activity of osteoblasts, the cells responsible for building new bone tissue. [2]
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Magnesium plays a key role in bone and mineral homeostasis, since it affects the formation/secretion of hormones that regulate skeletal homeostasis, bone cell function, and influences hydroxyapatite crystal formation and growth. [3]
Our Mg OSTEO Portfolio Exhibits
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Cohesion by forming a solid substrate that withstands less stress
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Adhesion with inherent attractive forces to both bone and metal
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Resorption via hydrolysis and osteoclastic enzyme breakdown- a natural process
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Remodeling Rates
Mg OSTEOCRETE remodeled nearly 4x more completely than competitive bone substitutes at 12 weeks.
Histomorphometric Evaluation (Rabbit Femur Bone Healing) and 510k Clearances K222063 and K071004
Pull Out Force
Mg OSTEOCRETE improved anchoring fixation by an average of 50% fifteen minutes post injection, and by 99% in poor quality bone, compared to Ca-Cement.
Use of a Novel Magnesium-Based Resorbable Bone Cement for Augmenting Anchor and Tendon Fixation. Am J Orthop (Belle Mead NJ). 2018;47(2). Roller BL, Kuroki K, Bozynski CC, Pfeiffer FM, Cook JL.
Peak Extraction Torque
Mg OSTEOCRETE demonstrated up to 58% greater extraction torque at 4 days compared to Ca-Cement and no treatment.
Degradable magnesium based cement adheres stainless steel screws into bone. Orthopaedic Research Society; 2006; Chicago, IL. Bertone A, DeMaria M, Johnson A, Weisbrode S, Kowaleski M.
Peak Extraction Torque
Mg OSTEOCRETE required up to 43% greater force to completely remove the bone screw as compared to Ca-Cement and no treatment at 5 days.
Influence of bone cements on bone-screw interfaces in the third metacarpal and third metatarsal bones of horses. Am J Vet Res. 2009;70(8):964-972. Hirvinen LJ, Litsky AS, Samii VF, Weisbrode SE, Bertone AL.
1, 2 Impact of magnesium on bone health in older adults: A systematic review and meta-analysis Inge Groenendijk, Marieke van Delft, Pieter Versloot, Luc J.C. van Loon b , Lisette C.P.G. M. de Groot
3 Monitoring bone changes due to calcium, magnesium, and phosphorus loss in rat femurs using Quantitative Ultrasound Aldo Fontes-Pereira, Paulo Rosa, Thiago Barboza, Daniel Matusin, Aline Soares Freire, Bernardo Ferreira Braz, Christiano Bittencourt Machado, Marco Antônio von Krüger, Sergio Augusto Lopes de Souza, Ricardo Erthal Santelli & Wagner Coelho de Albuquerque Pereira Scientific Reports volume 8, Article number: 11963 (2018)