Influence of Bone Cements on Bone-Screw Interfaces in the Third Metacarpal and Third Metatarsal Bones of Horses
Am J Vet Res. 2009; 70 (8) 964-972. Hirvinen LJ, Litsky AS, Samii VF, Weisbrode SE, Bertone AL
OsteoCrete
vs. Calcium Phosphate
43%
Increase of peak torque to failure
OsteoCrete
vs. PMMA
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21%
Increase of peak torque to failure
Degradable Magnesium-Based Cement Adheres Stainless Steel Screws Into Bone
Orthopaedic Research Society 2006; Chicago, IL. Bertone A, DeMaria M, Johnson A, Weisbrode S, Kowaleski M
OsteoCrete
vs. Calcium Phosphate
58%
Greater
extraction
torque
OsteoCrete
vs. PMMA
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27%
Greater
extraction
torque
Bone Graft Substitute Provides Metaphyseal Fixation for a Stemless Humeral Implant
Orthopedics 2015; 38 (7): e597-603. Kim MS, Kovacevic D, Milks RA, et al
OsteoCrete
vs. PMMA
28%
Greater
failure load
35%
More
failure cycles
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"This study demonstrates that OsteoCrete has short-term fixation similar to that of PMMA bone cement and may therefore provide sufficient mechanical support of a metaphysical implant in patients with poor bone quality where augmentation of implant fixation is desired."
Joseph P. Iannoti, MD, PhD, Cleveland Clinic
Use of a Novel Magnesium-Based Resorbable Bone Cement for Augmenting Anchor and Tendon Fixation
Am J Orthopedics. Belle Mead, NJ. 2018; 47 (2). Roller BL, Kuroki K, Bozynski CC, Pfeiffer FM, Cook JL
OsteoCrete
vs. Calcium Phosphate
83%
greater resorption at 12 weeks
35%
greater resorption at 26 weeks
84%
resorbed/replaced by woven bone at 26 weeks
Poor Quality Bone
99%
Increased
load-to-failure
15 min
post injection
50%
Increased
load-to-failure
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Effects of a Magnesium Adhesive Cement on Bone Stability and Healing Following a Metatarsal Osteotomy in Horses
Am J Vet Res. 2007; 68 (4) 370-378. Waselau M, Samii VF, Weisbrode SE, Litsky AS, Bertone AL
OsteoCrete
vs. Calcium Phosphate
More than 4x
more bone callus formation
20%
Reduction in fracture gap distance at
7 weeks
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88%
Increased callus area
A Magnesium Injectable Formulation Adheres Bone to Bone and Tendon to Bone
Orthopaedic Research Society 2005; Washington, D.C. Bertone A, Hackett B, Litsky A, Johnson A, Kaeding C, Lally T
OsteoCrete
vs. Calcium Phosphate
2.4x
Tensile load
to failure
on bone
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3.3x
Tensile load to failure
on tendon
Augmentation of Tendon-to-Bone Healing with a Magnesium-Based Bone Adhesive
Am J Sports Med. 2008; 36 (7) 1290-1297. Gulotta LV, Kovacevic D, Ying L, Ehteshami JR, Montgomery S, Rodeo SA
OsteoCrete
vs. No Treatment
Up to 2x
more
bone volume
Avg 47%
reduction of interface width/
less scar tissue formation
Up to 28x
more cartilage formation
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"The results of this study indicate that a magnesium-based bone adhesive can improve tendon-to-bone healing. It may eventually be possible to use this bone adhesive clinically to augment tendon-to-bone healing, potentially leading to increased attachment strength and a diminished risk of graft failure or slippage"
Scott A. Rodeo, MD, Hospital for Special Surgery