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Magnesium.

The bone solution from Bone Solutions, Inc.

Magnesium is critical for bone health and development. Approximately 60% of Magnesium in the body resides in the bones, contributing to the structural development of bone and playing a key role in the absorption and regulation of calcium. Magnesium also controls the active transport of calcium across cell membranes, and deficiency can contribute to osteoporosis. 

That is why Magnesium is the foundation of our portfolio. It creates the ultimate combination of stability, resorption, healing and adhesion to address even the most complex indications. 

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Initiates apatite layer formation on scaffolds

Enhances mineralization

of extracellular matrix

Enhances new bone formation through scaffold

Increases proliferation of marrow stromal cells

Improves attachment and growth of osteoblasts

Stimulates proteins for enhanced bone regeneration

 

Influence of Bone Cements on Bone-Screw Interfaces in the Third Metacarpal and Third Metatarsal Bones of Horses

Am J Vet Res. 2009; 70 (8) 964-972. Hirvinen LJ, Litsky AS, Samii VF, Weisbrode SE, Bertone AL

OsteoCrete

vs. Calcium Phosphate

43% 

Increase of peak torque to failure

OsteoCrete

vs. PMMA

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21% 

Increase of peak torque to failure

 

Degradable Magnesium-Based Cement Adheres Stainless Steel Screws Into Bone

Orthopaedic Research Society 2006; Chicago, IL. Bertone A, DeMaria M, Johnson A, Weisbrode S, Kowaleski M

OsteoCrete

vs. Calcium Phosphate

58% 

Greater

extraction

torque

OsteoCrete

vs. PMMA

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27% 

Greater 

extraction

torque

Bone Graft Substitute Provides Metaphyseal Fixation for a Stemless Humeral Implant

Orthopedics  2015; 38 (7): e597-603. Kim MS, Kovacevic D, Milks RA, et al

OsteoCrete

vs. PMMA

28% 

Greater

failure load

35% 

More

failure cycles

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"This study demonstrates that OsteoCrete has short-term fixation similar to that of PMMA bone cement and may therefore provide sufficient mechanical support of a metaphysical implant in patients with poor bone quality where augmentation of implant fixation is desired."

Joseph P. Iannoti, MD, PhD, Cleveland Clinic

 

Use of a Novel Magnesium-Based Resorbable Bone Cement for Augmenting Anchor and Tendon Fixation

Am J Orthopedics. Belle Mead, NJ. 2018; 47 (2). Roller BL, Kuroki K, Bozynski CC, Pfeiffer FM, Cook JL

OsteoCrete

vs. Calcium Phosphate

83% 

greater resorption at 12 weeks

35% 

greater resorption at 26 weeks

84% 

resorbed/replaced by woven bone at 26 weeks

Poor Quality Bone

99% 

Increased

load-to-failure 

15 min

post injection

50% 

Increased

load-to-failure 

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Effects of a Magnesium Adhesive Cement on Bone Stability and Healing Following a Metatarsal Osteotomy in Horses

Am J Vet Res. 2007; 68 (4) 370-378. Waselau M, Samii VF, Weisbrode SE, Litsky AS, Bertone AL

OsteoCrete

vs. Calcium Phosphate

More than 4x 

more bone callus formation

20% 

Reduction in fracture gap distance at

7 weeks

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88% 

Increased callus area

 

A Magnesium Injectable Formulation Adheres Bone to Bone and Tendon to Bone

Orthopaedic Research Society 2005; Washington, D.C. Bertone A, Hackett B, Litsky A, Johnson A, Kaeding C, Lally T

OsteoCrete

vs. Calcium Phosphate

2.4x 

Tensile load

to failure

on bone

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3.3x 

Tensile load to failure

on tendon

 

Augmentation of Tendon-to-Bone Healing with a Magnesium-Based Bone Adhesive

Am J Sports Med. 2008; 36 (7) 1290-1297. Gulotta LV, Kovacevic D, Ying L, Ehteshami JR, Montgomery S, Rodeo SA

OsteoCrete

vs. No Treatment

Up to 2x 

more

bone volume

Avg 47% 

reduction of interface width/

less scar tissue formation

Up to 28x 

more cartilage formation

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"The results of this study indicate that a magnesium-based bone adhesive can improve tendon-to-bone healing. It may eventually be possible to use this bone adhesive clinically to augment tendon-to-bone healing, potentially leading to increased attachment strength and a diminished risk of graft failure or slippage"

Scott A. Rodeo, MD, Hospital for Special Surgery

Bone Solutions, Inc.

5712 Colleyville Blvd., Suite 210

Colleyville, Texas 76034

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© 2020 by Bone Solutions, Inc.

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