Magnesium.
The bone solution from Bone Solutions, Inc.
Magnesium is critical for bone health and development. Approximately 60% of Magnesium in the body resides in the bones, contributing to the structural development of bone and playing a key role in the absorption and regulation of calcium. Magnesium also controls the active transport of calcium across cell membranes, and deficiency can contribute to osteoporosis.
That is why Magnesium is the foundation of our portfolio. It creates the ultimate combination of stability, resorption, healing and adhesion to address even the most complex indications.
Initiates apatite layer formation on scaffolds
Enhances mineralization
of extracellular matrix
Enhances new bone formation through scaffold
Increases proliferation of marrow stromal cells
Improves attachment and growth of osteoblasts
Stimulates proteins for enhanced bone regeneration
Influence of Bone Cements on Bone-Screw Interfaces in the Third Metacarpal and Third Metatarsal Bones of Horses
Am J Vet Res. 2009; 70 (8) 964-972. Hirvinen LJ, Litsky AS, Samii VF, Weisbrode SE, Bertone AL
OsteoCrete
vs. Calcium Phosphate
43%
Increase of peak torque to failure
OsteoCrete
vs. PMMA
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21%
Increase of peak torque to failure
Degradable Magnesium-Based Cement Adheres Stainless Steel Screws Into Bone
Orthopaedic Research Society 2006; Chicago, IL. Bertone A, DeMaria M, Johnson A, Weisbrode S, Kowaleski M
OsteoCrete
vs. Calcium Phosphate
58%
Greater
extraction
torque
OsteoCrete
vs. PMMA
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27%
Greater
extraction
torque
Bone Graft Substitute Provides Metaphyseal Fixation for a Stemless Humeral Implant
Orthopedics 2015; 38 (7): e597-603. Kim MS, Kovacevic D, Milks RA, et al
OsteoCrete
vs. PMMA
28%
Greater
failure load
35%
More
failure cycles
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"This study demonstrates that OsteoCrete has short-term fixation similar to that of PMMA bone cement and may therefore provide sufficient mechanical support of a metaphysical implant in patients with poor bone quality where augmentation of implant fixation is desired."
Joseph P. Iannoti, MD, PhD, Cleveland Clinic
Use of a Novel Magnesium-Based Resorbable Bone Cement for Augmenting Anchor and Tendon Fixation
Am J Orthopedics. Belle Mead, NJ. 2018; 47 (2). Roller BL, Kuroki K, Bozynski CC, Pfeiffer FM, Cook JL
OsteoCrete
vs. Calcium Phosphate
83%
greater resorption at 12 weeks
35%
greater resorption at 26 weeks
84%
resorbed/replaced by woven bone at 26 weeks
Poor Quality Bone
99%
Increased
load-to-failure
15 min
post injection
50%
Increased
load-to-failure
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Effects of a Magnesium Adhesive Cement on Bone Stability and Healing Following a Metatarsal Osteotomy in Horses
Am J Vet Res. 2007; 68 (4) 370-378. Waselau M, Samii VF, Weisbrode SE, Litsky AS, Bertone AL
OsteoCrete
vs. Calcium Phosphate
More than 4x
more bone callus formation
20%
Reduction in fracture gap distance at
7 weeks
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88%
Increased callus area
A Magnesium Injectable Formulation Adheres Bone to Bone and Tendon to Bone
Orthopaedic Research Society 2005; Washington, D.C. Bertone A, Hackett B, Litsky A, Johnson A, Kaeding C, Lally T
OsteoCrete
vs. Calcium Phosphate
2.4x
Tensile load
to failure
on bone
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3.3x
Tensile load to failure
on tendon
Augmentation of Tendon-to-Bone Healing with a Magnesium-Based Bone Adhesive
Am J Sports Med. 2008; 36 (7) 1290-1297. Gulotta LV, Kovacevic D, Ying L, Ehteshami JR, Montgomery S, Rodeo SA
OsteoCrete
vs. No Treatment
Up to 2x
more
bone volume
Avg 47%
reduction of interface width/
less scar tissue formation
Up to 28x
more cartilage formation
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"The results of this study indicate that a magnesium-based bone adhesive can improve tendon-to-bone healing. It may eventually be possible to use this bone adhesive clinically to augment tendon-to-bone healing, potentially leading to increased attachment strength and a diminished risk of graft failure or slippage"
Scott A. Rodeo, MD, Hospital for Special Surgery